Flares, jets and quasi-periodic outbursts from neutron star merger remnants

Using numerical relativity simulations with a subgrid dynamo prescription to generate strong initial magnetic fields, we investigate the possibility of launching a jet-like outflow from the hypermassive neutron star (HMNS) during the early stages of the merger, prior to the remnants collapse to a black hole. We demonstrate that buoyant instabilities in the strongly magnetized HMNS can lead to a periodic emission of powerful electromagnetic flares shortly after the merger. These are followed by a collimated mildly relativistic outflow. Both types of outflows feature quasi-periodic kilohertz substructure. These early-time outflows may power precursors to short-duration gamma-ray bursts (SGRB) or in some cases the entire SGRB. While the overall temporal power spectrum we find broadly agrees with the one recently reported for quasi-periodic oscillations in the SGRB GRB910711, our simulations suggest that the periodic electromagnetic substructure is dominated by magnetohydrodynamic shearing processes rather than correlating with the corresponding post-merger gravitational wave signal.Comment: 10 pages, 6 figure

Design, analysis and fabrication of an articulated mobile manipulator

The process involved in designing, fabricating and analysing a mobile robotic manipulator to carry out pick and place task in a dynamic and unknown environment has been explained here. The manipulator designed and fabricated has a 5 – axis articulated arm for pick and place application but also can be reconfigured to do other tasks. The manipulator is built with its driving or power means fitted at the bottom to distribute the load effectively and also make handling easier. The mobile platform employs a novel suspension system which helps in relatively distributing the load equally to all wheels regardless of the wheels position giving the mobile platform better control and stability. With reference to many available manipulators and mobile platforms in the market, a practical design is perceived using designing tools and a fully functional prototype is fabricated. The kinematic model determining the end effector’s position and orientation is analysed systematically and presented. Navigational controls are built using fuzzy logic and genetic algorithm with the help of the sensors’ information so that the robot can negotiate obstacle while carrying out various tasks in an unknown environment. The path tracking for pick-and-place application is the overall target of this industrial manipulator

Forging connections: anthologies, arts collectives, and the politics of inclusion

The changing social and political landscape of twentieth-century Britain catalysed a remarkable rise in collaborative activity by artists and activists of black and Asian heritage. Creative communities began to gather in both local and regional contexts, with the aim of sharing resources and securing an audience. This chapter records some of these many activities, tracing the groups’ genesis, manifest objectives, and key contributions. It argues that anthologising should be understood as a specifically motivated activity. Literary anthologies of poetry and fiction served to showcase the diversity of contemporary writing, while also suggesting its coherence. Drawing on the concept of “strategic essentialism” elucidated by Gayatri Chakravorty Spivak, I show that the anthology acts to ensure the visibility of a group, bannered as a unified and singly-titled selection of texts, while also insisting on the differences within: the heterogeneous multiplicity of black and Asian British experiences and creative practices

DESIGN & KINEMATIC ANALYSIS OF AN ARTICULATED ROBOTIC MANIPULATOR

This paper describes the design, fabrication and analysis a five axes articulated robotic manipulator. The current work is undertaken by considering various commercially available robotic kits to design and fabricate a five degree of freedom (D.O.F) arm. Forward kinematic model has been presented in order to determine the end effectors position and orientation. Although this work is still in primary level, this analysis is useful for path tracking of an industrial manipulator with pick-and-place application. Based on this analysis, a researcher can develop path tracking behaviour of an end effector in complicated work space

Short Bowel Syndrome and Kidney Transplantation: Challenges, Outcomes, and the Use of Teduglutide

Among patients with short bowel syndrome who commonly have kidney disease, kidney transplantation remains challenging. We describe the clinicopathologic course of a 59-year old man with short bowel syndrome secondary to Crohn’s disease who underwent a deceased donor kidney transplant that was complicated by recurrent acute kidney allograft injury due to volume depletion from diarrhea, ultimately requiring the placement of permanent intravenous access for daily volume expansion at home resulting in the recovery of allograft function. Teduglutide treatment at 1.8 years post-transplant led to a dramatic decrease in diarrhea. A literature review of similar cases yielded 18 patients who underwent 19 kidney transplants. Despite high rates of complications, at the time of last follow-up (median 2.1 years [0.04-7]), 94% of the patients were still alive and 89% had functioning allografts, with a median eGFR of 37.5 [14-122] ml/min/1.73m2. In conclusion, despite high rates of complications, kidney transplantation in patients with short bowel syndrome is associated with acceptable short- and midterm outcomes. Further, we report for the first time the effects of the glucagon-like peptide-2 analogue teduglutide for short bowel syndrome in a kidney transplant recipient

Efficacy and Safety of Direct Acting Antivirals in Kidney Transplant Recipients with Chronic Hepatitis C Virus Infection

The prevalence of Hepatitis C Virus (HCV) infection is significantly higher in patients with end-stage renal disease compared to the general population and poses important clinical challenges in patients who undergo kidney transplantation. Historically, interferon-based treatment options have been limited by low rates of efficacy and significant side effects, including risk of precipitating rejection. Limited data exist on the use of all-oral, interferon-free direct-acting antiviral (DAA) therapies in kidney transplant recipients. In this study, we performed a retrospective chart review with prospective clinical follow-up of post-kidney transplant patients treated with DAA therapies at three major hospitals in Boston, MA. A total of 24 kidney recipients with HCV infection received all-oral DAA therapy post-transplant. Patients were predominantly male (79%) with a median age of 60 years (range 34–70 years), median creatinine of 1.2 mg/dL (0.66–1.76), and 42% had advanced fibrosis or cirrhosis. The majority had HCV genotype 1a infection (58%). All patients received full-dose sofosbuvir; it was paired with simeprevir (9 patients without and 3 patients with ribavirin), ledipasvir (7 patients without and 1 patient with ribavirin) or ribavirin alone (4 patients). The overall sustained virologic response (SVR12) was 91% (21 out of 23 patients). One patient achieved SVR4 but demised prior to SVR12 check point due to treatment unrelated cause. Two treatment failures were successfully retreated with alternative DAA regimens and achieved SVR. Both initials failures occurred in patients with advanced fibrosis or cirrhosis, with genotype 1a infection, and prior HCV treatment failure. Adverse events were reported in 11 patients (46%) and were managed clinically without discontinuation of therapy. Calcineurin inhibitor trough levels did not significantly change during therapy. In this multi-center series of patients, all-oral DAA therapy appears to be safe and effective in post-kidney transplant patients with chronic HCV infection